Scientific studies, particularly conducted by the scientists of the Thai Mangosteen Research and Development Center (TMRDC) at Asian Phytoceuticals Public Company Limited (APCO), have established the following activities of xanthones:

1. Growth inhibition and the ability to kill antibiotic-resistant gram-positive bacteria, with an effectiveness aquivalent to that of vancomycin.

2. Anti-inflammatory, 3 times more effective than aspirin.

3. Analgesic (pain relieving) and anti-allergy.

4. Anti-oxidant – preventing heart diseases from LDL cholesterol oxidation.

5. Kill breast cancer cells, leukemia cells, liver cancer cells, kidney cancer cells, stomach/intestinal cancer cells, and lung cancer cells (based on laboratory testing).

6. Kill tuberculosis bacterium (based on laboratory testing).

7. Inhibit the propagation of HIV (based on laboratory testing).

8. Increase the phagocytosis, the cellular process of eliminating foreign matters and bacteria.

9. Inhibit cartilage deterioration and increase bone mass (based on laboratory testing).

GM-1 has been found by scientists at TMRDC to be the most active amongst 41 xanthones in mangosteen.

References:

1. J. Nat.Prod. 1987 May-June 50(3) 474-8.

2. J. Sci. Soc. Thailand, 12(1986) 239-242.

3. Free Radic Res. 2000 Nov;33(5):643-59.

4. Planta Med. 1996 Aug;62(4):381-2.

5. Free Radic Res. 1995 Aug;23(2):175-84.

6. J Pharmacol Sci. 2004 May;95(1):33-40.

7. J Med Assoc Thai. 1997 Sep;80 Suppl 1:S149-54.

8. Chem Pharm Bull (Tokyo). 2003 Jul; 51(7):857-9.

9. M.Sc. in Pharmacology Thesis, Chiang Mai University 1998. (Ajchara Chaikaeo)

10. M.Sc. in Organic Chemistry Thesis, Prince of Songkla University 1985. (Wilawan Mahabusarakam)

Because of the broad spectrum of pharmacological activities, mangosteen juice containing xanthones has been used, particularly in the United States, to increase the body's ability to cope with pain, fever, inflammation, diarrhea, bacterial and viral infections, atherosclerosis, aging, arthritis, mouth ulcers, intestinal ulcers, stomach ulcers and cancer.

To obtain a more efficacious formulation than the ordinary mangosteen juice, GM-1 mixed with its synergistic herbal extracts is added to the juice.

In the latest studies, scientists at TMRDC have found significant results which shed light on how GM-1 acts on the body's systems, modulates immunity, and is responsible for the wide spectrum of activities. This has led us to believe that GM-1 will help the body to cope not only with the aforementioned physical complaints, but also with Alzheimer's, diabetes, osteoporosis, depression, anxiety, Parkinson’s disease, cataracts, glaucoma, vertigo, high blood pressure, and other autoimmune-related diseases.